HTML
<div class="reference" tabindex="0"><div class="popout-menu">Popout menu</div></div>
  
CSS
.reference {
  position: relative;
  background: tomato;
  width: 100px;
  height: 100px;
}
.popout-menu {
  position: absolute;
  visibility: hidden;
  left: 100%;
  background: #333;
  color: white;
  padding: 15px;
}
.reference:hover > .popout-menu,
.reference:focus > .popout-menu,
.reference:focus-within > .popout-menu {
  visibility: visible;
}