.wrapper {
  display: flex;
  flex-flow: row wrap;
}

/* We tell all items to be 100% width, via flex-basis */
.wrapper > * {
  flex: 1 100%;
}

/* We rely on source order for mobile-first approach
 * in this case:
 * 1. header
 * 2. article
 * 3. aside 1
 * 4. aside 2
 * 5. footer
 */

/* Medium screens */
@media all and (min-width: 600px) {
  /* We tell both sidebars to share a row */
  .aside { flex: 1 auto; }
}

/* Large screens */
@media all and (min-width: 800px) {
  /* We invert order of first sidebar and main
   * And tell the main element to take twice as much width as the other two sidebars 
   */
  .main { flex: 3 0px; }
  .aside-1 { order: 1; }
  .main    { order: 2; }
  .aside-2 { order: 3; }
  .footer  { order: 4; }
}