df = pd.DataFrame(np.random.randint(32, 120, 100000).reshape(50000,2),columns=list('AB')) df['A'] = df['A'].apply(chr) %timeit dict(zip(df.A,df.B)) %timeit pd.Series(df.A.values,index=df.B).to_dict() %timeit df.set_index('A').to_dict()['B']
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