Preview:
const omit = (obj, arr) =>
  Object.keys(obj)
    .filter(k => !arr.includes(k))
    .reduce((acc, key) => ((acc[key] = obj[key]), acc), {});

omit({ a: 1, b: '2', c: 3 }, ['b']); // { 'a': 1, 'c': 3 }
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