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"Good night".replace("night", "day")
// "Good day"

// some with ignoreCase
"Good night".replace("night", "day", true)
// true mean ignoreCase=true

for c in df_drop.columns:
    df_drop[c] = df_drop[c].str.replace('[^\w\s]+', '')
df_drop = df_drop.astype(str)
df_drop.head()

String.replace() ways of using